F48 showed the common somatic mutation signature of IDH-mutant astrocytomas comprising the IDH/TP53/ATRX triad [3]: IDH1 p.R132H, TP53 p.I232S with LOH, and ATRX p.H2252R, which represents a novel ATRX mutation (Fig. 2a, b; Additional file 1: Table S2). This evidence concerns the gene TP53 and astrocytoma (excluding glioblastoma).