FGFR3 and central nervous system cancer: Histologically, the FGFR3 glioblastomas showed intense GFAP reactivity and various degrees of “FGFR3-TACC3 glioma recurrent morphological features” [21], in addition to high-grade (HG) features, such as brisk mitotic activity, necrosis and microvascular proliferation (Additional file 1: Fig. S1).