We characterized in this study a spectrum of FGFR alterations from a cohort of 101 WHO grade IV diffuse gliomas, including novel FGFR2 and FGFR3 fusions, the former taking place in IDH-mutant glioblastoma, a neoplasm previously not known to harbor oncogenic FGFR alterations [9]. The gene discussed is FGFR3; the disease is glioblastoma.