Mutant HTT impairs vesicle formation from recycling endosome by interfering with RAB11 activity [42], which is disrupted in a knockin mouse model of HD [41] and slows the recycling of the EAAC1 glutamate/cysteine transporter to the plasma membrane, leading to deficient glutathione synthesis and oxidative stress [43]. Here, HTT is linked to Huntington disease.