Consistently, gene ontology (GO) analysis of the differentially expressed genes in the PRMT1- or SMARCA4-knockdown versus NC controls revealed significant enrichment of genes involved in several key cellular processes such as EGFR signaling pathways, cell proliferation, and cell division or migration, which correlated with cancer progression (Additional file 1: Fig. S4c). The gene discussed is SMARCA4; the disease is cancer.