We determined that one mechanism by which SMARCA4 promotes CRC progression is via the epigenetic regulation of TNS4 and EGFR. SMARCA4 is recruited to the TNS4 and EGFR promoter through binding PRMT1-mediated H4R3me2a, leading to enhanced proliferation and migration of CRC cells, as well as formation of colorectal tumors in mice. Here, PRMT1 is linked to colorectal neoplasm.