In contrast to cancer cells, either upregulation or downregulation of Regnase-1 in primary-culture chondrocytes via infection of Ad-Regnase-1 and Ad-shRegnase-1, respectively, did not modulate the mRNA levels of apoptosis-associated Fas, Bad, or Bcl3 (Supplementary Fig. 4A). The gene discussed is BCL3; the disease is cancer.