Altogether, data show DEspR expression across the CSC-plasticity spectrum spanning CSCs, cscTCs, TCs, and CSC micro-clusters, and demonstrate variations in molecular marker-based subsets (DEspR±, CD133±), thus confirming CSC-heterogeneity as seen in human PDAC [8] and other cancers [10]. The gene discussed is FBXW7-AS1; the disease is cancer.