To determine the effects of DEspR inhibition on Panc1-CSC and cscTC mesenchymal functions relevant to peritoneal dissemination, we assessed alpha-smooth muscle actin (αSMA) expression, and concomitant downstream expression and release of collagen-1 (Col1A1) given their prometastatic functionality and potential contritubution to desmoplasia in the tumor microenvironment. This evidence concerns the gene ACTA1 and neoplasm.