A recent research unveiled that serum Apo-A1 levels showed strong negative correlation with systemic inflammatory markers including serum CRP and interleukin (IL)-8 levels and blood neutrophil count in 144 colorectal cancer patients [24], which indicate systemic inflammation may influence tumorigenesis and regulate lipid metabolism in the same period, thus, enabling some kinds of serum lipid markers to correlate with tumor characteristics and provide prognostic information. The gene discussed is APOA1; the disease is neoplasm.