Through gene enrichment analysis and a review of the existing literature and Pubmed database, we identified nine CNV regions associated with the development of NAFLD, including chr2 (24347959-24390254, GSTT1), Chr14 (74001651-74022324, ACOT1), chr20 (33470663-33495348, ACSS2), Chr7 (54813380-55274871, EGFR), chr1 (65935075-65959904, LEPR), Chr3 (57199594-57590187, APPL1), chr12 (57897795-57918452, CHOP), chr19 (56370486-56416408, NLRP4) and chr17 (38688567-38738474, CCR7). The gene discussed is APPL1; the disease is metabolic dysfunction-associated steatotic liver disease.