A previous study found that CHOP knockout (CHOP-/-) mice fed a high-fat diet developed more severe histological NASH features than wild-type controls;The severity of NASH in high-fat diet-fed CHOP−/− mice correlated with a significant decrease in peroxisomal β-oxidation, increased denovo lipogenesis, and ER stress-mediated hepatocyte apoptosis [44]. The gene discussed is DDIT3; the disease is metabolic dysfunction-associated steatohepatitis.