To specifically address the role of Zeb1-induced EMT in PDAC progression, we deleted Zeb1 in cancer cells of a second version of the KPC model with homozygous loss rather than a dominant negative mutation of p53 (KrasG12D; p53F/F; p48-Cre; YFPLSL, hereafter referred to as KPPC). This evidence concerns the gene ZEB1 and cancer.