NPPB and hydrops fetalis: After a median 12-year follow-up, among subjects with baseline NT-proBNP < 190 ng/L, those who showed a biomarker increase > 25% between the two measurements had a higher risk of developing HF (HR 2.13 [1.68–2.71]) or die of cardiovascular causes (HR 1.91 [1.43–2.53]) compared to those with stable NT-proBNP values [31].