In a cohort of 2,130 patients of the Gruppo Italiano per lo Studio della Sopravvivenza nell’Insufficienza Cardiaca (GISSI-HF) study, NGAL, KIM-1, and NAG were independently associated with the combined endpoint of death or HF hospitalization, even in patients with normal renal function [110]. The gene discussed is HAVCR1; the disease is hydrops fetalis.