In the Dallas Heart study, which included 3148 individuals (51% Black, 31% White, 18% Hispanic) without major cardiovascular diseases (myocardial infarction, HF, or stroke), median NT-proBNP levels were significantly lower (p < 0.0001) in Black subjects (24 [10–52] ng/L) compared to Hispanics (30 [14–59] ng/L) and Whites (32 [16–62] ng/L) [49]. The gene discussed is NPPB; the disease is hydrops fetalis.