TIMP1 and hydrops fetalis: Similarly, in a sub-analysis of the Prospective Comparison of ARNI With ARB Global Outcomes in HF With Preserved Ejection Fraction (PARAGON-HF), treatment with sacubitril/valsartan led to a significant reduction of some degradation products such as TIMP-1 and PIIINP at a 16-month follow-up, compared to valsartan [98].