Discharge NPs seem more effective than admission values for risk stratification, as demonstrated in an analysis of 7039 patients with acute HF enrolled in the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failure (OPTIMIZE-HF), where discharge BNP was more predictive of 1-year death (hazard ratio [HR] 1.34 [95% confidence interval, 1.28–1.40]) and 1-year death or hospitalization (HR 1.15 [1.12–1.18]) than admission BNP [21]. The gene discussed is NPPB; the disease is hydrops fetalis.