Conversely, European Society of Cardiology (ESC) guidelines recommend the use of BNP and NT-proBNP for the exclusion of HF (class IIa, LOE C), with reference values < 100 ng/L and < 300 ng/L for acute HF, respectively, and < 35 ng/L and < 125 ng/L for chronic HF, respectively [2] (Table 2). This evidence concerns the gene NPPB and hydrops fetalis.