In an analysis of 3346 subjects without clinical evidence of HF followed for an average of 5 years, baseline BNP or NT-proBNP > 80th percentile were associated with a significantly higher risk of new-onset HF (BNP: HR 3.07 [1.51–6.26], p = 0.002; NT-proBNP: HR 5.02 [2.32–10.85], p < 0.001) [29]. The gene discussed is NPPB; the disease is hydrops fetalis.