IL6 and neoplasm: Ingenuity pathway analysis revealed granulocyte adhesion/diapedesis, liver X receptor/retinoid X receptor activation, acute phase signaling, and IL-6 signaling among the top pathways associated with cachexia in adipose tissue (Fig. S4, A–D), with changes in gene expression similar across both tumor conditions, while iPathway highlighted cytokine signaling, metabolism, and JAK-STAT signaling (Fig. 6 E).