Moreover, IL-6 is sufficient to induce cachexia in mice (Baltgalvis et al., 2009; Chen et al., 2016; Tsujinaka et al., 1996) as well as lipolysis and atrophy in cultured adipocytes (Trujillo et al., 2004) and myotubes (Bonetto et al., 2012), respectively. The gene discussed is IL6; the disease is Cachexia.