LC3B-II and ATF4 protein were increased in the muscle of KPC but not KPC IL6KO tumor–bearing mice (Fig. 4, C and D), while Beclin-1 was unchanged in muscle of mice with KPC tumors and actually decreased in muscle of mice with KPC IL6KO tumors (Fig. 4, C and D). This evidence concerns the gene ATF4 and neoplasm.