IL6 and cancer: IL-6 levels are high in PDAC models with weight loss (Flint et al., 2016), and IL-6 is functionally linked to cachexia in murine C26 colon adenocarcinoma and other models of cancer cachexia (Baltgalvis et al., 2008; Bonetto et al., 2012; Bonetto et al., 2011; Narsale and Carson, 2014).