Although circulating IL-6 levels are not always detectable in early PDAC nor always correlated with cachexia severity (Ramsey et al., 2019; Talbert et al., 2018), higher tumor staining for IL-6 is associated with PDAC cachexia (Martignoni et al., 2005) and induction of monocyte IL-6 is predictive of survival in PDAC (Moses et al., 2009), suggesting that the serum levels of this short-lived cytokine might not be an appropriate measure of tissue activity. The gene discussed is IL6; the disease is Cachexia.