We attribute the majority of Il6 induction to adipocytes in fat and the majority of Il6r to myofibers in muscle and not from nonparenchymal cell types in either tissue because mononuclear cells isolated from those tissues do not demonstrate equivalent induction versus the whole tissue in mice with cachexia versus shams (Fig. 7, G and H; myofibers and adipocytes are eliminated in these mononuclear cell preparations due to size). Here, IL6 is linked to Cachexia.