The GSEA data indicated that, in the c2 category, the high expression of ADAMTS6 may participate in extracellular matrix organization, development of advanced GC, metastasis, ECM receptor interaction, vascular endothelial growth factor A (VEGFA), kirsten rat sarcoma viral oncogene (KRAS), c-Jun N-terminal kinase (JNK), and cadherin (CDH1) signaling pathways (Figure 13A–I). The gene discussed is MAPK8; the disease is gastric cancer.