The Cytotoxic T-Lymphocyte Antigen 4 (CTLA-4) [7] and the programmed death-1 (PD-1) and programmed death-1 ligand (PD-L1) [8] represent a key point regarding escape from immune surveillance by cancer cells, and this reason has led to the development of antibodies against these molecules. The gene discussed is CD274; the disease is cancer.