COL4A3 and Microscopic hematuria: In our cohort, microscopic hematuria data were reported for 9 patients with pathogenic variants and 8 patients with a variant of uncertain significance in COL4A3 and COL4A5. Microscopic hematuria was observed in 4 of 9 patients with pathogenic variants and 2 of 8 patients with a variant of uncertain significance (Tables S2 and S3).