DNMT1 and acute myeloid leukemia: In corollary, direct or indirect role of CCDC26 in retaining DNMT1 in nucleus and also maintaining cell proliferation can explain why CCDC26 is often upregulated in AML (Duployez et al., 2018; Izadifard et al., 2018; Kuhn et al., 2012; Radtke et al., 2009).