In instances other than during embryonic development, cytosolic localization of DNMT1 tends to be aberrant; for example, it has been associated with several neurological disorders including hereditary sensory and autonomic neuropathy type 1E (HSAN1E) (Baets et al., 2015), Alzheimer disease (Mastroeni et al., 2013) and Parkinson disease (Desplats et al., 2011), as well as cancer tumorigenesis (Arzenani et al., 2011; Hodge et al., 2007). The gene discussed is DNMT1; the disease is early-onset autosomal dominant Alzheimer disease.