However, experts in MeCP2, Rett’s Syndrome and autism commented that symptoms observed in the macaques are less severe than those of human patients, some human MeCP2-duplication symptoms are absent (e.g., seizures), and expression of the gene in the macaque could be triggered by a different mechanism from that in humans, so caution should be exercised in using the model to make assumptions about human autism (Cryanoski, 2016; Dunhaime-Ross, 2016; Zeliadt, 2017; Katsnelson, 2018). This evidence concerns the gene MECP2 and Rett syndrome.