PKM and inflammatory bowel disease: Besides, many biomarkers for IBD, such as antiglycan antibodies, leucine-rich alpha-2 glycoprotein (LRG), and pyruvate kinase M2 (PKM2), in serum have been explored recently, but they had some weak points in sensitivity and specificity for diagnosis of IBD (Almousa et al., 2018; Shinzaki et al., 2017; Simondi et al., 2008).