Previous studies have shown that COL1A1 can participate in glutamine-mediated interaction between pancreatic cancer and stellate cells (Chakravarthy et al., 2018), and silencing COL1A1(siCOLIA1) inhibited the orthotopic growth of colorectal tumor in mice (Wu et al., 2020). The gene discussed is COL1A1; the disease is familial pancreatic carcinoma.