In summary, 16 genes were selected from the 106 top ccRCC lineage preferential dependency candidates derived from DepMap, an integrated large-scale RNAi and CRISPR/Cas9 screening project of hundreds of human cell lines; these genes included B4GALT4, BCL2L1, CDH2, COPG1, CRB3, FERMT2, GET4, GPX4, HNF1B, ITGAV, MDM2, NFE2L2, PAX8, RUVBL1, TFRC, and TNFSF10. This evidence concerns the gene RUVBL1 and nonpapillary renal cell carcinoma.