In summary, 16 genes were selected from the 106 top ccRCC lineage preferential dependency candidates derived from DepMap, an integrated large-scale RNAi and CRISPR/Cas9 screening project of hundreds of human cell lines; these genes included B4GALT4, BCL2L1, CDH2, COPG1, CRB3, FERMT2, GET4, GPX4, HNF1B, ITGAV, MDM2, NFE2L2, PAX8, RUVBL1, TFRC, and TNFSF10. Here, NFE2L2 is linked to nonpapillary renal cell carcinoma.