Although a significant increase in CA125 and CA19-9 is considered a valuable indicator for cancer diagnosis 41, 42, with continuous science development, many scholars have found that CA125 and CA199 has a varying degree of increase and significance in the diagnosis of non-malignant diseases, such as heart failure 43, active tuberculosis 44, inflammatory bowel disease 45, liver cirrhosis 46, and other diseases. Here, MUC16 is linked to heart failure.