IGHE and helminthiasis: This is in line with the decrease in IgE-mediated allergic responses mediated by DF and SCFAs.10 However, DF and SCFAs exacerbate helminth infections and related inflammatory responses (Table 2).7 This is because IgE is a key effector molecule in defense against helminth infection, and therefore, decreased IgE levels can weaken antihelminth immune responses.