NLRP3 and colitis: IL-37d transgenic mice show increased resistance to DSS-induced acute colitis and inhibition of NLRP3 inflammasome overactivation.228 In addition, peritoneal tissue-resident macrophages lacking the tissue-specific transcription factor GATA6 robustly suppressed IL-1β processing through the action of Gata6-mediated production of prostacyclin and IL-10.229 Further studies will be needed to evaluate the regulatory effect of a wide range of cytokines on NLRP3 inflammasome activation.