Small heterodimer partner (SHP), an orphan nuclear receptor, physically interacts with NLRP3 and suppresses activation of the NLRP3 inflammasome.223 Nuclear receptor related 1 (Nurr1/NR4A2) ameliorates the activation of Müller cells and the cell death of retinal ganglion cells in a diabetes model through suppression of NF-κB action and inhibition of NLRP3 inflammasome component expression, such as NLRP3 and ASC.224 However, some nuclear receptors may function in the activation of the NLRP3 inflammasome. The gene discussed is NR0B2; the disease is diabetes mellitus.