Autophagic adapter SQSTM1-mediated autophagy leads to degradation of pyruvate kinase muscle (PKM), thereby inhibiting the production of mature IL1B in LPS-ATP-treated macrophages and ameliorating synovial inflammation.205 PTEN-induced kinase 1 (PINK1)/Parkin-mediated mitophagy suppresses mtROS and NLRP3 inflammasome-related renal injury in renal tubular epithelial cells (RTECs) during contrast-induced acute kidney injury.206. This evidence concerns the gene PINK1 and acute kidney injury.