NR4A2 and diabetes mellitus: Small heterodimer partner (SHP), an orphan nuclear receptor, physically interacts with NLRP3 and suppresses activation of the NLRP3 inflammasome.223 Nuclear receptor related 1 (Nurr1/NR4A2) ameliorates the activation of Müller cells and the cell death of retinal ganglion cells in a diabetes model through suppression of NF-κB action and inhibition of NLRP3 inflammasome component expression, such as NLRP3 and ASC.224 However, some nuclear receptors may function in the activation of the NLRP3 inflammasome.