Under conditions of cytosolic DNA stimulation and herpes simplex virus type 1 (HSV-1) infection, stimulator of interferon genes (STING) promotes NLRP3 inflammasome activation through recruitment and interaction with NLRP3 via attenuation of K48- and K63-linked polyubiquitination.52 Given that aberrant activation of the cGAS-cyclic GMP-AMP (cGAMP)-STING pathway leads to inflammation, senescence, and cancer,53,54 it is difficult to clarify the potential detrimental effects of the cGAS-STING pathway on NLRP3 licensing for inflammasome assembly. This evidence concerns the gene CGAS and cancer.