NLRP3 and neoplasm: The lncRNA ADAMTS9-AS2, a tumor suppressor, enhances cisplatin sensitivity in gastric cancer cells by activating NLRP3-mediated pyroptotic cell death by sponging miR-223-3p.217 In addition, knocking down the lncRNA NEAT1 inhibits inflammasome activation through induction of miR-3076-3p targeting NLRP3, thereby expanding the tolerogenic phenotype of dendritic cells.218 One important future direction of study involves investigating the mechanisms of cross talk between miRNAs and lncRNAs in the modulation of NLRP3 inflammasome activation and pyroptotic cell death.