Notably, in bronchial cells of patients with cystic fibrosis, Pseudomonas aeruginosa infection results in impaired autophagy, thereby activating the NLRP3 inflammasome and hyperinflammation in cystic fibrosis pulmonary disease.204 Importantly, defective CFTR channels are associated with decreased capacity for selective autophagic clearance of P. aeruginosa infection in cystic fibrosis bronchial cells.204 The precise mechanism linking CFTR channels to selective autophagy activation remains to be determined. This evidence concerns the gene NLRP3 and cystic fibrosis.