RIPK3 and renal fibrosis: For example, sirtuin 3, a major deacetylase involved in mitochondrial homeostasis, is required to control the expression of necroptosis-related RIPK1, RIPK3, and NLRP3, as well as to prevent mitochondrial injury and mtROS, thereby exerting a protective effect in diabetic cardiomyopathy.164 In addition, the RIPK3 inhibitor dabrafenib was shown to be beneficial for amelioration of renal fibrosis, the pathogenesis of which is associated with RIPK3-regulated NLRP3 inflammasome activation.165