In line with those mentioned above that VEGF-induced GLUT1 upregulation in BBB endothelial cells [see section: glycolysis in the blood–brain barrier endothelial cells], the increased level of VEGF is released by myeloid cells since specific deletion of VEGF on myeloid cell significantly reduces GLUT1 expression and impairs glucose uptake in BBB endothelial cells, resulting in cognitive deficits. The gene discussed is VEGFA; the disease is Cognitive impairment.