CPE and neoplasm: HNC displayed higher mean methylation when taking all cytosines together (paired wilcox test p-value = 9.501e−08, mean methylation of non-tumors = 0.58%, mean methylation in tumors = 0.68%), or CpG sites (paired wilcox test p-value = 4.19e−05, mean methylation of non-tumors = 5.12%, mean methylation in tumor = 5.96%) and CpH sites (paired wilcox test p-value = 0.0002, mean methylation of non-tumors = 0.12%, mean methylation in tumors = 0.15%) independently.