While untreated Golm1−/− mice exhibited no morphological abnormality (Supplementary Fig. 1b–d), the treated Golm1−/− mice displayed an increased colon tumor burden and an enhanced colon to body weight ratio compared to WT mice (Fig. 1e, f and Supplementary Fig. 1e, f). Here, GOLM1 is linked to digestive system neoplasm.