Genetic inactivation of GOLM1 in myeloid cells suppresses interleukin (IL)-12 secretion and polarizes marcophage towards M2 type.22 Moreover, GOLM1 overexpression has been identified in virus-associated inflammatory liver diseases.23 GOLM1 also promotes HCV replication by inhibiting type I interferon production.22 The potential role of GOLM1 in colonic inflammatory diseases is, however, unclear. This evidence concerns the gene GOLM1 and liver disorder.