GOLM1 (Golgi membrane protein 1, also referred to as GP73 or Golph2), a Golgi type II transmembrane protein, expresses variedly in different tissues.14 Overexpressed GOLM1 has been recognized as an oncogenic protein in many malignancies, including hepatocellular carcinoma,15 prostate cancer,16 lung cancer,17–19 breast cancer,20 renal cancer21, and glioblastoma.16 Despite these findings, its impact on CRC has yet to be elucidated. Here, GOLM1 is linked to Familial prostate cancer.