BRD4 and familial pancreatic carcinoma: Given that the BRD4 inhibitor JQ1 downregulated NR5A2 expression, we speculated that BRD4 might transcriptionally activate the expression of NR5A2. BRD4 overexpression in pancreatic cancer cells significantly upregulated NR5A2 both at the mRNA and protein levels (Fig. 4D, E).