SPP1 and cancer: We also found that the increased expression of PPP1CB, RAC1, and SPP1 was correlated with increased drug resistance of cancer cells to several chemotherapy drugs, such as Tegafur, Dabrafenib, Entinostat, Fluorouracil, By-Product of CUDC-3, Denileukin Diftitox Ontak, Bisacofyl (active ingredient), Acetalax and Tyrothricin (cor > 0.27 and P < 0.05).