At least three different MAPK signal transduction pathways participate in the modulation and transduction of extracellular signals into the nucleus to induce response genes in such mammalian cells as ERK1/2, JNK1/2/3, and p38 [44, 45], and all of them have proved to be correlated with HCC [46–48]. This evidence concerns the gene MAPK8 and hepatocellular carcinoma.