MAPT and Alzheimer disease: To that end, it is crucial to study the distribution of tau deposition in bvAD, as this central neuropathological hallmark of AD is closely related to type and severity of cognitive symptoms9 and precedes and predicts patterns of neurodegeneration detected by MRI and [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET).10 11 In this study, we aimed to investigate the regional distribution of tau pathology in bvAD (i) in-vivo using tau PET and (ii) ex-vivo using postmortem examination.