To determine if YTHDF3 is a factor involved in the innate antiviral response, we depleted YTHDF3 in A375 and T3M4 cells prior to infection with PVSRIPO (MOI 10) or transfection with high molecular weight (HMW) poly(I:C) and examined activation of antiviral signaling (Fig. 3). The gene discussed is YTHDF3; the disease is infection.