HeLa (cervical carcinoma, human papillomavirus 18 infected) and SUM149 (breast cancer) cells permit rampant early viral translation and efficient eIF4G1 cleavage (substantial reduction of intact eIF4G1 prior to 6 hpi) and do not mount effective antiviral host responses to PVSRIPO (multiplicity of infection [MOI] 10). Here, EIF4G1 is linked to breast cancer.