Here, on the basis of Nox3-Cre;tdTomato, which can be used as a reporter system (Nox3-Cre+/−;tdTomato+/+ and Nox3-Cre+/+;tdTomato+/+), and Nox3-KO (Nox3-Cre+/+;tdTomato+/+) mice, we demonstrate that Nox3 inhibition in the cochlea is a promising strategy for ROS-related SNHL, such as cisplatin-induced HL, age-related HL, and noise-induced HL. Here, NOX3 is linked to Hodgkins lymphoma.