While the present results do not address the neural substrates responsible for AMPH pro-cognitive effects in schizophrenia patients, we (Swerdlow et al., 2018) and others (Goldberg et al., 1991) proposed that these AMPH effects may reflect the preferential activation of prefrontal D1-family receptors by AMPH-induced dopamine release under conditions of antipsychotic-induced D2-family blockade; we were able to reproduce related AMPH effects in rodent models under varying levels of D1- and D2 receptor blockade (Swerdlow et al., 2018). This evidence concerns the gene AMPH and schizophrenia.