In in vitro experiments, the expression of osteogenic genes (BMP2, BSP, OCN, OPN, Runx2) and osteogenic proteins (COL1, OCN, BMP2) and the staining of osteogenic markers (ALP, collagen, mineralization) indicated that EMF significantly improved the osteogenic ability of BMSCs cultured in OM. The gene discussed is RUNX2; the disease is ocular melanoma.