To further explore the relationship between PD-L1-lnc and PD-L1 mRNA, we either overexpressed PD-L1-lnc using a PD-L1-lnc vector or depleted PD-L1-lnc using a PD-L1-lnc shRNA in lung cancer cells and then monitored the cellular levels of PD-L1 mRNA and PD-L1 protein. The gene discussed is CD274; the disease is lung cancer.