In contrast, when PD-L1-lnc was depleted in lung cancer cells via transfection with PD-L1-lnc-specific shRNA, the proliferation (Fig. 4a) and invasion (Fig. 4b) of cancer cells were significantly reduced, whereas the apoptosis of cancer cells (Fig. 4c) was increased, compared to untreated cancer cells. The gene discussed is CD274; the disease is lung cancer.