The present study reveals that PD-L1-lnc, an alternatively spliced product of the PD-L1 gene, promotes LUAD proliferation, metastasis, and survival via enhancing c-Myc transcriptional activity, and also argues in favor of investigating PD-L1-lnc depletion in combination with PD-L1 blockade in lung cancer therapy. The gene discussed is CD274; the disease is lung cancer.