For the first time in this study, to the best of our knowledge, the small 9-amino acid Os-pep, which is considered an adiponectin-mimetic peptide, was evaluated for its effect on memory and learning functions in well-established AβO-treated and APP/PS1 transgenic mouse models of memory deficits and AD as well as in Adipo−/− mice; it was recently reported that Adipo−/− mice have deficits in learning and memory functions [14, 16]. This evidence concerns the gene PSEN1 and Alzheimer disease.