ADIPOQ and congestive heart failure: However, adipokines, particularly adiponectin and its receptor, should be thoroughly monitored for translation-based studies because of recent findings and epidemiological studies that reported that an excess adiponectin level is associated with lethal effects, such as circulatory disorders (chronic heart failure & chronic kidney failure), as well as other undesirable effects, such as weight loss, low skeletal muscle mass/density, and physical functioning impairment, which ultimately lead to morbidity and mortality [26–31].