MAPT and Alzheimer disease: Of note, considering the adiponectin paradox and the very recent amyloidogenic evolvability theory [24, 25, 74], we suggest that future translational studies of this adiponectin-mimetic nonapeptide be performed, and the therapeutic effects of Os-pep on Aβ aggregation and the hyperphosphorylation of tau proteins as well as the regulation of cellular homeostasis will be tested in animal models at different stages of AD, such as transgenic mice that are 12 ~ 24 months old as well as SAMP8 (senescence-accelerated) mice as late-onset (sporadic) AD models.