Most importantly, in this study, Os-pep, as an adiponectin-mimetic nonapeptide that functions as a ligand for AdipoR1 to trigger AdipoR1/AMPK signaling, subsequently decreased neuronal insulin resistance and increased pre- and postsynaptic protein markers as well spine morphogenesis in the hippocampal neuronal CA1 region of Adipo−/− and AβO mice. The gene discussed is ABO; the disease is Insulin resistance.