Moreover, we observed for the first time that the dosage regimen of Os-pep improved LTP and cognitive functions such as learning and memory via the activation of AdipoR1 in normal AβO-injected and transgenic APP/PS1 mouse models of AD and in Adipo−/− mice, as measured using the MWM and Y-maze tests. The gene discussed is PSEN1; the disease is Alzheimer disease.