Furthermore, to assess mechanistically the roles of AdipoR1/AMPK signaling and neuronal insulin resistance, we analyzed the two main pre- and postsynaptic protein markers (synaptophysin (Synap) and postsynaptic density protein (PSD95), respectively) in human neuronal SH-SY5Y cells overexpressing APPswe/ind and expressing AdipoR1 siRNA and in APPswe/ind-overexpressing SH-SY5YIR cells exposed to AdipoR1 siRNA and treated with Comp. The gene discussed is ADIPOR1; the disease is Insulin resistance.