Based on these observations, Os-pep chronic administration (5 μg/g, i.p., on alternating days for 45 days) rescued the memory deficits associated with aberrant neuronal metabolic-associated AD pathology via activation of AdipoR1-dependent processes, and these results corroborate and validate the above in vivo and in vitro biochemical and immunohistological results. Here, ADIPOR1 is linked to Alzheimer disease.