Furthermore, Os-pep treatment (5 μg/g, i.p., on alternating days for 45 days) regulated the levels of various biochemical parameters associated with metabolic disorders and AD in the serum of both APP/PS1, HFD and Adipo−/− mice (Fig. S3a-d; Fig. S4a-d). This evidence concerns the gene PSEN1 and Other metabolic disease.