To explore the impacts of AS on the functions of cyclinL2 in PC cells, we generated CyclinL2△exon6.3+ (CCNL2-S) and CyclinL2△exon6.3− (CCNL2-L) lentivirus, and evaluated how they could change the malignant behaviors of PANC-1 cells. This evidence concerns the gene CCNL2 and pachyonychia congenita.