Pre-treatment CEA elevation, T2 stage, tumor distance from anal verge, close distal resection margin, lymphovascular invasion, perineural invasion, young age, male gender, ulcerative gross appearance (rather than polypoid appearance), and anastomotic leakage have been reported for risk factors of tumor recurrence, time to recurrence, and/or the recurrence patterns [5–10]. This evidence concerns the gene CEACAM5 and neoplasm.