Five weeks of TRF improved menstruation, gonadal profiles (TT, SHBG and FAI), body weight, BMI, body composition profiles (BFM, BF% and VFA), hyperinsulinemia and insulin resistance profiles (FINS, HOMA-IR, AUCIns and AUCIns/AUCGlu), decreasing ALT, hsCRP and increasing IGF-1 in a group of fifteen young women with anovulatory PCOS. The gene discussed is IGF1; the disease is Hyperinsulinemia.