A key phenotypic endpoint in psoriasis is epidermal hyperplasia and the uncontrolled epidermal growth is strongly attributed by cytokines and growth factors which include IL-17, IL-22, EGF, and IGF-1, all together accelerates keratinocyte transit time and mitotic index up to tenfold compared to normal skin [12, 51]. The gene discussed is IL22; the disease is psoriasis.