TSC2 and ischemic stroke: The recent study by Amani et.al, found that c Se nanoparticles has therapeutic effects on ischemic stroke through the protection of axons in hippocampus region, as well as myelination of hippocampal area along with the resolution of brain edema after cerebral ischemic stroke and with minimal side effects, through the regulation of wnt/β-catenin signaling, mTOR, Tsc1/Tsc2 complex, FoxO1 hippo, Ubiquitin–proteasome system (ERK5) which are playing a prominent role in inflammation [64].