In multivariate logistic regression analysis, cT stage (cT4 vs cT2-3, HR = 2.837, p = 0.040), tumor site (lower vs upper, HR = 7.683, p = 0.004; middle vs upper, HR = 3.562, p = 0.058) and CFP (High vs Low, HR = 3.693, p = 0.002) remained significantly associated with TRG. The gene discussed is CFP; the disease is neoplasm.