Multivariate analysis showed that both CFP score (HR = 6.635, p = 0.003), ypTNM stage (HR = 4.785, p = 0.02), perineural invasion (HR = 4.904, p = 0.009), tumor deposits (HR = 7.932, p < 0.001), and FARI (HR = 3.642, p = 0.013) were independent prognostic indicator of DFS in LARC patients undergoing radical surgery following NCRT. The gene discussed is CFP; the disease is neoplasm.