Since CEA [7], FARI [20] and PNI [21] have all been found to serve as indicators of the prognosis and tumor response of LARC patients, we constructed a combination of these markers and investigated the prognostic and predictive role of the combination (CEA-FARI-PNI, CFP) in 138 LARC patients undergoing radical surgery following NCRT and compared its prognosis predicted efficacy with CEA, FARI and PNI. The gene discussed is CFP; the disease is neoplasm.