Among newborns of mothers with hypercholesterolemia, female compared to male newborns had significantly higher plasma concentrations of several cholesterol metabolites, phosphatidylcholines, sphingomyelins, ApoB, ApoA1, degree of fatty acid unsaturation, omega-6 fatty acids (%), polyunsaturated fatty acids (%), LDL size, and particle concentration of intermediate-density lipoprotein, LDL, and HDL subclasses (multivariable 0.001 ≤ q ≤ 0.098, Figs. 3 and 4 and Additional files 1 and 4). This evidence concerns the gene APOB and familial hypercholesterolemia.