FOXO3 and neoplasm: Meanwhile, IFN-beta-WJMSCs and IFN-beta-hBMMSCs exhibited the ability to suppress tumor growth in bronchioloalveolar carcinomas [202] and HCCs, respectively, the latter exerting its effect by increasing expression of p21, p27 and FOXO3a, as well as decreasing protein levels of cyclin D1, pRb and AKT [203].