A Chinese study found that HSD3B1 (Hydroxy-Delta-5-Steroid Dehydrogenase, 3 Beta- and Steroid Delta-Isomerase 1) rs6428829 and AAT haplotype, and HSD17B3 (Hydroxysteroid 17-Beta Dehydrogenase 3) H8 haplotype were significantly associated with acne risk [53]. The gene discussed is HSD3B1; the disease is acne.