TYK2 and acne: Other SNPs that were significantly associated with acne presentation: ACE (angiotensin-converting enzyme) I/D VNTR [17], MMP2 (Matrix metalloprotease 2) rs2285053 [28]; severe acne: MAPK11 (mitogen-activated protein kinase 11) rs144991069, SEMA4B (semaphorin 4B) rs34560261, SELL (selectin L) rs7531806, TGFB2 (transforming growth factor beta 2) rs1256580 [11], TNFRSF1B rs1061622 [32], TRAF3IP2 (TRAF3 Interacting Protein 2) rs33980500 [26]; and teenage acne: TYK2 (tyrosine kinase 2) rs12720356 [26].