DDB2 and acne: Our meta-analysis revealed that the FST rs629725 A allele poses a significantly modest increased risk for acne [pooled OR: 1.19, 95% CI: 1.14, 1.23; no significant heterogeneity observed (I2 = 48.9%, p = 0.141); Fig. 4e], while the DDB2 rs747650 G allele also poses a negligible increased risk for acne [pooled OR: 1.03 (95% CI: 1.00, 1.05), albeit with significant heterogeneity observed (I2 = 88.0%, p = 0.000); Fig. 4d].