CYP1A1 and acne: Two CYP1A1 candidate SNPs were also studied where no significant association with acne was found: + 4889 A/G SNP in the German population [48] and + 6235 T/C SNP (rs4646903) in Indonesian [47], German [48] populations and in our meta-analysis [pooled OR: 0.95, 95% CI: 0.83, 1.08; no significant heterogeneity observed (I2 = 0%, p = 0.587); Fig. 5c].