Begg’s funnel plot and Egger’s test showed that there was statistically significant publication bias for the meta-analysis of TNF rs1800629 acne presentation, mild acne and severe acne; SELL rs7531806; PPARG rs1801282; and CYP17A1 rs743572 acne presentation, moderate acne and severe acne. The gene discussed is CYP17A1; the disease is acne.