NLRP3 and acne: In contrast, SNPs that showed no significant association with acne risk, include EGFR (epithelial growth factor receptor) variants rs2293347, rs2227983, CA repeat intron 1 VNTR [59], ITLN1 (Intelectin-1/Omentin) Val109Asp [24], MMP2 (matrix metallopeptidase 2) − 1306 C/T [27], NLRP3 (NLR family pyrin domain containing 3) rs4612666 [73], and TIMP2 (TIMP metallopeptidase inhibitor 2) − 418 G/C [27, 28].