Meta-analysis of SELL rs7531806 and TGFB2 rs1256580 SNPs found that the minor alleles posed a significantly increased risk for acne—pooled OR was 1.06 (95% CI: 1.03–1.09) and 1.11 (95% CI: 1.07–1.16), respectively, albeit with significant heterogeneity observed (I2 = 89.4%, p = 0.000; I2 = 82.6%, p = 0.003, respectively; Fig. 4a, 4b). This evidence concerns the gene SELL and acne.