Finally, two recent bioinformatics studies using gene expression data of the lesional and nonlesional skin of acne patients from the NCBI Gene Expression Omnibus found 12 top upregulated differentially expressed genes (DEGs) involved in immune and inflammatory responses, namely FPR2, ITGB2, CXCL8, C3AR1, CXCL1, FCER1G, LILRB2, PTPRC, SAA1, CCR2, ICAM1, and FPR1 [86, 87]. This evidence concerns the gene CXCL1 and acne.