Lastly, IL8 − 251 T/A SNP was found to be significantly associated with acne and acne severity among Pakistanis [61], but not among Polish [18]; meta-analysis of these and our study showed that this SNP was not significantly associated with acne, as the pooled OR was 1.03 (95% CI: 0.91–1.15), with no significant heterogeneity observed (I2 = 61.2%, p = 0.076; Fig. 3c). This evidence concerns the gene CXCL8 and acne.