Gene variants that were significantly associated with severe acne risk include: DDB2 (damage specific DNA binding protein 2) rs747650 and rs1060573 [10], MUC1 (mucin 1) 20aa VNTR [54], FST (follistatin) rs629725, LAMC2 (laminin subunit gamma 2) rs10911268, LGR6 (leucine rich repeat containing G protein-coupled receptor 6) rs788790, OVOL1 (ovo like transcriptional repressor 1) rs144991069, SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like) rs28360612, and WNT10A (Wnt family member 10A) rs121908120 [11]. This evidence concerns the gene OVOL1 and acne.