These inflammatory mediators activate the nuclear factor kappa-B (NF-κB), a pro-proliferation and survival factor, pathway and form a complex with the YY1 transcription factor to create transcriptional regulatory loops [47]. CDKN2B-AS1 abundance can also be induced by exposure to hypoxia (a well-known phenomenon associated with the tumor microenvironment). The gene discussed is CDKN2B; the disease is neoplasm.