In addition, the PI3K/AKT/mTOR signaling pathway positively regulates the Warburg effect by upregulating the expression of GLUTs and lactate dehydrogenase (LDH) and stimulating glutaminolysis in tumor cells (Courtnay 2015; Bao et al. 2015; Guo 2016). This evidence concerns the gene MTOR and neoplasm.