CASP3 and liver cancer: 2012), Hep2 liver cancer (Khalil et al. 2015) and MCF-7 breast (Khoja et al. 2011; Alshatwi et al. 2013) was based on caspases-3 and −8 (Al-Daghri et al. 2012; Alshatwi et al. 2013; Khalil et al. 2015), and caspase-9 (Khoja et al. 2011). It was found that apoptosis of MCF-7 breast cancer cells triggered by methanol extract from T. foenum-graecum seeds occurs as a result of stimulation of the external – receptor pathway (Alshatwi et al. 2013).