2020). For example, vitexin induced ROS production in a dose-dependent manner and increased the expression of autophagy marker proteins in colorectal cancer cells (Bhardwaj et al. 2017). In the study of active constituents of Prosopis cineraria (L.)Druce (Fabaceae), vitexin had dose- and time-dependent anti-proliferative activity in chronic myeloid leukaemia (K-562) cell line and induced apoptosis through reducing superoxide dismutase (SOD) activity and elevating ROS, nitric oxide (NO), and malondialdehyde (MDA) levels (Sarkar et al. 2020). This evidence concerns the gene SOD1 and colorectal cancer.