To investigate mechanisms of neural-specific expression of the clustered PCDH genes in the brain, we performed REST/NRSF ChIP-nexus experiments in model cells of neuroblastoma SK-N-SH and endometrial carcinoma HEC-1-B (33,36,38) and found 5276 and 9681 REST/NRSF sites, respectively (Figure 1C). The gene discussed is REST; the disease is neuroblastoma.