Among known DUBs, ubiquitin-specific protease 7 (USP7), also known as herpes virus-associated ubiquitin-specific protease (HAUSP) (11), as it was originally identified as a herpes simplex virus type 1 Vmw110-interacting protein (12) and as a key regulator of p53 (13–15) is implicated in multiple cellular processes such as DNA repair (16), cytokinesis (17), DNA replication (18), innate immune responses (19), viral replication and infection (20) and mitosis progression (21). Here, USP7 is linked to infection.