In contrast, downregulated miRNA-150 expression has been identified in lymphoma, acute myeloid leukemia, pancreatic cancer, esophageal squamous, colorectal cancer (CRC), and hepatocellular carcinoma, where miRNA-150 targets several oncogenes such as Akt, MUC4, ZEB1, and c-Myb [25, 28, 29]. This evidence concerns the gene MUC4 and familial pancreatic carcinoma.