To investigate why CCDC6-RET protein granule formation is kinase-independent, we swapped the fusion partners EML4 and CCDC6 to generate two additional oncogenic RTK fusion oncoproteins that are also present in human cancers, EML4-RET and CCDC6-ALK (Hillier et al., 2019; Iams and Lovly, 2018). Here, CCDC6 is linked to cancer.