CKD robustly upregulated PPP3CA (Supplemental Figure 8A) and promoted the nuclear translocation of NFATc3 (Supplemental Figure 8B) in cardiac tissues, whereas AAV2/9-miR-30-Zsgreen treatment significantly attenuated this calcineurin signaling activation (Supplemental Figure 8, A and B). The gene discussed is NFATC3; the disease is chronic kidney disease.