And the plasma levels of CXCL1 were significantly correlated with TT genotype of TRAF3IP2 (rs33980500) in myocardial infarction patients.[47] Whereas, CXCL8 may mediate the recruitment and activation of neutrophils, and promote the formation of new blood vessels.[48] In addition, CXCL8 is upregulated in the infarct area inducing polymorphonuclear leukocyte infiltration.[49] It was reported that CXCL1 and CXCL8 participate in pathogenic processes of several cancers, such as colorectal cancer, non-small cell lung cancer, and gastric carcinoma.[50–52]. This evidence concerns the gene CXCL8 and cancer.